Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility.
نویسندگان
چکیده
منابع مشابه
Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility.
We have carried out nanosecond fluorescence polarization studies of genetically engineered immunoglobulins to determine the structural features controlling their segmental flexibility. The proteins studied were hybrids of a relatively rigid isotype (mouse IgG1) and a relatively flexible one (mouse IgG2a). They have identical light chains and heavy chain variable regions and have the same combin...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.8.2509